Evolocumab in Patients without a Previous Myocardial Infarction or Stroke
PCSK9 inhibition with evolocumab led to a lower risk of first cardiovascular events than placebo among patients with atherosclerosis or diabetes and without a previous myocardial infarction or stroke. (Funded by Amgen; VESALIUS-CV ClinicalTrials.gov number, NCT03872401.).
Authors
- José Carlos Nicolau (ORCID: https://orcid.org/0000-0002-9680-3689)
- V. Bláha (ORCID: https://orcid.org/0000-0001-8088-9919)
- Julia Kuder (ORCID: https://orcid.org/0000-0002-7099-1538)
- Róbert Gábor Kiss (ORCID: https://orcid.org/0000-0003-0514-7530)
- Erin A. Bohula (ORCID: https://orcid.org/0000-0002-5559-8172)
- Marcoli Cyrille (ORCID: https://orcid.org/0000-0002-7139-2916)
- Gabriel Paiva da Silva Lima (ORCID: https://orcid.org/0000-0001-8073-719X)
- Edward P. Walsh (ORCID: https://orcid.org/0000-0001-6203-4415)
- Huei Wang (ORCID: https://orcid.org/0000-0002-9903-1979)
- E. Magnus Ohman (ORCID: https://orcid.org/0000-0002-6249-4988)
- Robert P. Giugliano (ORCID: https://orcid.org/0000-0003-4110-7675)
- Gaetano Maria De Ferrari (ORCID: https://orcid.org/0000-0003-4940-0876)
- Alberto Lorenzatti (ORCID: https://orcid.org/0000-0003-4180-2010)
- Lawrence A. Leiter (ORCID: https://orcid.org/0000-0002-1040-6229)
- Sabina A. Murphy (ORCID: https://orcid.org/0000-0002-8231-3611)
- Nicholas Marston (ORCID: https://orcid.org/0000-0001-6164-4617)
- Ajay Bhatia
- Marc S. Sabatine
- Alexander Parkhomenko
- Assen Goudev
- Jan H. Cornel
- Jeong-Gun Park
- Andrzej Budaj
Institutions
- Semmelweis University (HU)
- St. Michael's Hospital (CA)
- Amgen (United States) (US)
- University of Toronto (CA)
- Queen Giovanna Hospital (BG)
- Medical University of Sofia (BG)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Noordwest Ziekenhuisgroep (NL)
- Instituto Médico DAMIC (AR)
- University Hospital Hradec Králové (CZ)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- National Scientific Center "M.D. Strazhesko Institute of Cardiology" (UA)
- Grochowski Hospital (PL)
- Thrombolysis in Myocardial Infarction Study Group (US)
Publication Details
- Journal
- New England Journal of Medicine
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1056/nejmoa2514428
- Citations
- 30
- Primary Topic
- Lipoproteins and Cardiovascular Health
- Type
- article
- Field-Weighted Citation Impact
- 60.19