Nickel-Catalyzed 3,2-Hydroallylation of 1,1-Disubstituted Allenes with Vinyl Cyclopropanes: Access to Functionalized 1,4-Dienes
A Ni(II)-catalyzed regioselective 3,2-hydroallylation of 1,1-disubstituted allenes has been developed using vinyl cyclopropanes as allyl precursors, providing efficient access to highly functionalized 1,4-dienes. The presence of a carbonyl functionality in the cyclopropane substrate enables a modified 1,6-type nucleophilic addition pathway via ring opening. A tailored N<sup>∧</sup>N-type ligand was found to be essential for promoting the transformation under NiH catalysis.
Authors
- Ujjwal Karmakar
- Eun Jin Cho (ORCID: https://orcid.org/0000-0002-6607-1851)
- Haeryeong Jeong
Institutions
- Chung-Ang University (KR)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1021/acs.orglett.5c04270
- Citations
- 1
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.94