Protein Tyrosine Phosphatase 4A1 (PTP4A1) Regulates Early Events in Colorectal Cancer Intraperitoneal Dissemination in the Aged Male Host
These results provide a resource for comparative proteomics of the peritoneal mesothelial cell in sex- and age-based cohorts. Functional data support further consideration of PTP4A1 as a potential therapeutic target for impeding CRC metastasis particularly in an aged male cohort.
Authors
- Marwa Asem
- Gena Dominique
- Daniel D. Hu (ORCID: https://orcid.org/0000-0003-1903-6516)
- Jinmin Miao (ORCID: https://orcid.org/0000-0001-7471-0847)
- Jonas Carlson (ORCID: https://orcid.org/0000-0002-9135-9814)
- M. Sharon Stack (ORCID: https://orcid.org/0000-0003-4563-7390)
- Jeffrey Johnson
- Matthew M. Champion (ORCID: https://orcid.org/0000-0001-5927-5277)
- Yueying Liu
- Wanrui Wang
- Tyvette S. Hilliard (ORCID: https://orcid.org/0000-0003-2076-6620)
- Reihaneh Safavi‐Sohi (ORCID: https://orcid.org/0000-0001-9824-5740)
- Elizabeth I. Harper (ORCID: https://orcid.org/0000-0002-3547-1692)
- Yunpeng Bai (ORCID: https://orcid.org/0000-0002-6973-581X)
- Jing Yang (ORCID: https://orcid.org/0000-0002-1718-9183)
- Zhong‐Yin Zhang (ORCID: https://orcid.org/0000-0001-5527-7910)
- Zhikun Wang (ORCID: https://orcid.org/0009-0001-0326-8673)
- William Milosevich
Institutions
- University of Notre Dame (US)
- Seton Hall University (US)
- Johns Hopkins University (US)
- Purdue University West Lafayette (US)
- Johns Hopkins Medicine (US)
- AbbVie (United States) (US)
- Tuskegee University (US)
Publication Details
- Journal
- Aging and Cancer
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1002/aac2.70008
- Primary Topic
- Protein Tyrosine Phosphatases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Walther Cancer Foundation