Genetic differences in the HLA region contribute to the variability in SARS‐CoV‐2 vaccine responsiveness of older persons: the Doetinchem Cohort Study
Genetic variation is suggested to play a role in the primary vaccine-induced IgG antibody responses to SARS-CoV-2 in older persons. The most prominent source of variation was found to lie in HLA genes, which are enriched in several immune pathways and immune-mediated diseases.
Authors
- M. Liset Rietman (ORCID: https://orcid.org/0000-0002-1796-7037)
- Yunus Kuijpers (ORCID: https://orcid.org/0000-0002-5075-3970)
- H. Susan J. Picavet (ORCID: https://orcid.org/0000-0002-6895-165X)
- Peter Engelfriet (ORCID: https://orcid.org/0000-0001-7221-3599)
- W. M. Monique Verschuren (ORCID: https://orcid.org/0000-0003-2134-4227)
- Anne‐Marie Buisman (ORCID: https://orcid.org/0000-0001-5085-7844)
Institutions
- University Medical Center Utrecht (NL)
- National Institute for Public Health and the Environment (NL)
Publication Details
- Journal
- Clinical & Translational Immunology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1002/cti2.70058
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00