Peptide hormone spexin restores beta cell function and improves glycaemic control in mice via regulation of the sodium–potassium pump
Our study highlights that spexin is a stimulatory factor for beta cell function and proliferation, and suggests that spexin is a diabetes therapeutic target for beta cell intervention.
Authors
- Chao Tang (ORCID: https://orcid.org/0000-0003-1474-3705)
- Shan Liu (ORCID: https://orcid.org/0009-0004-2999-6718)
- Yunzhi Ni (ORCID: https://orcid.org/0000-0003-2453-2522)
- Jiarong Dai (ORCID: https://orcid.org/0000-0002-2804-4019)
- Yehong Yang (ORCID: https://orcid.org/0000-0003-3600-2174)
- Rui Liu (ORCID: https://orcid.org/0000-0002-8321-1617)
- Anran Ma (ORCID: https://orcid.org/0000-0003-1831-0851)
- Quanya Sun (ORCID: https://orcid.org/0000-0002-8446-4480)
- Changlong Hu (ORCID: https://orcid.org/0000-0002-8609-8947)
- Yaojing Jiang (ORCID: https://orcid.org/0009-0004-9119-2745)
- Jiangchao Qian (ORCID: https://orcid.org/0000-0002-0316-2959)
- Ying Liu (ORCID: https://orcid.org/0000-0002-9341-2674)
- Huixia Ren (ORCID: https://orcid.org/0000-0002-1761-6018)
- Chengfang Pan (ORCID: https://orcid.org/0009-0007-4503-8570)
- Yiming Li (ORCID: https://orcid.org/0000-0002-1828-8765)
- Di Wu (ORCID: https://orcid.org/0000-0003-1802-4855)
- Hangping Zheng (ORCID: https://orcid.org/0000-0003-2812-2176)
- G. Qin (ORCID: https://orcid.org/0009-0009-1876-0095)
- Hao Yin (ORCID: https://orcid.org/0009-0002-9286-7236)
- Lan Ji (ORCID: https://orcid.org/0009-0007-5264-179X)
Institutions
- Second Military Medical University (CN)
- Peking University (CN)
- Fudan University (CN)
- Shanghai Clinical Research Center (CN)
- Huashan Hospital (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1007/s00125-025-06596-z
- Citations
- 1
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43