S784 Efficacy of Bowel Regimen on GLP1-RA-Induced Constipation

Introduction: The class of long acting glucagon-like peptide-1 receptor agonists (GLP-1 RA) has become prevalent in modern medical practice. Their effects on delayed gastric emptying have been increasingly concerning, particularly in regard to procedures. This delayed gastric emptying with GLP1-RAs commonly result in constipation as a common side effect. Our study aimed to investigate the effectiveness of various bowel regimen treatments in patients who developed constipation after starting GLP-1 RA therapy. Methods: A single-center, retrospective study in the outpatient setting was performed to evaluate the effects of various bowel regimens on GLP-1 induced constipation. Data was queried utilizing an electronic patient data registry and included information on patient demographics, medication usage, and outcome variables. Statistical analyses comprised descriptive statistics, chi-square testing were used to address the primary study endpoints. A post hoc analysis for their respective primary statistical analyses for head-to-head comparison of different bowel regimens. Results: Our cohort consisted of 410 patients who received one of nine GLP-1 RAs and one of nine bowel regimens. Logistic regression analysis was performed to assess the effect of diabetes, patient age, sex, baseline constipation, and specific type of GLP-1 RA on the odds of developing constipation after both GLP-1 RA use and subsequent bowel regimen initiation. The results revealed that younger age and usage of post-GLP-1 RA laxative were the only factors that reduced risk of constipation, odds ratio (OR) 0.977, (95% confidence interval [CI] 0.959-0.996) and OR 0.431, (95% CI 0.279-0.663) respectively. Chi-square testing did not show a significant difference in constipation reduction between bowel regimens P = 0.182. Proportional z-score analysis for rates of GLP-1 RA induced constipation by bowel regimen was significant at P < 0.05. Post-hoc analysis revealed significant differences among various bowel regimens with most superior to psyllium. Conclusion: As GLP-1 RA becomes increasingly prevalent in our society, their use is typically associated with worsening constipation. Although there was no significant difference observed between specific GLP-1 RA resulting in causing constipation or bowel regimen to improve constipation. We did identify most bowel regimen were more superior compared to psyllium.