S909 Incidence Rate of Barrett's Esophagus in Hispanics Has Almost Doubled Over the Last Fifteen Years

Introduction: Barrett’s esophagus (BE) has been considered a disease of middle-aged White men. Classic risk factors include age >50 years, White race, male sex, history of gastroesophageal reflux disease (GERD), obesity, and smoking. Studies examining the prevalence of BE report that White patients have a higher incidence of BE than Black and Hispanic patients. To date, no studies evaluated the incidence of BE in Hispanic patients over time. Thus, the aim of the study is to identify changes in BE prevalence in Hispanic patients, using a large national dataset. Methods: An analysis of nationwide population-based database was conducted using the United States TriNetX Platform. Hispanic patients diagnosed with BE in the years 2010 and 2024 were included. New diagnoses of BE were divided by the total number of Hispanic patients who presented for medical care visits each year to calculate the incidence rate of BE among Hispanic patients within that year. Demographic data, including major known risk factors for BE, were compared between the 2 groups. Statistical analyses were conducted with unpaired Student’s t-test for continuous variables and Chi square test of independence for categorical variables. Significance was determined at an alpha level = 0.05. Results: In the year 2010, 278 Hispanic patients on the TriNetX database were diagnosed with BE, assessing 1,216,536 medical visits among Hispanic patients (22.9 cases per 100,000 visits). In contrast, there were 1,386 Hispanic patients diagnosed with BE in 2024 among 3,333,178 visits (41.6 cases per 100,000 visits). The incidence rate ratio (IRR) was 1.8 cases of BE in Hispanic patients in 2024 compared to 2010. Compared to Hispanic patients diagnosed with BE in 2010, those diagnosed in 2024 were older (mean age 59.7 years vs 57.2 years; P = 0.0077), more likely to be White Hispanic (55% vs 44%; P = 0.0008), and have body mass index (BMI) ≥30 (28% vs 11%; P < 0.0001). While a greater percentage of those diagnosed in 2024 had a history of nicotine dependence (19% vs 14%) and had a personal history of gastroesophageal reflux disease (77% vs 73%), these did not reach statistical significance. Almost half of Hispanic patients diagnosed with BE in 2024 were women (49% in 2024 vs 42% in 2010), though this did not reach significance. Conclusion: The incidence of BE among Hispanic patients is rising, with the IRR nearly doubling over the past 15 years. Identified risk factors include advanced age, White race, and elevated BMI.