S1160 Understanding the Psychiatric Profile and Sociodemographics of Adults With Irritable Bowel Syndrome: A 10-Year Multicenter Electronic Health Record Analysis

Introduction: Irritable bowel syndrome (IBS) is frequently accompanied by psychiatric comorbidities that may exacerbate symptom burden and drive healthcare utilization. Contemporary, population-level estimates of mental-health disorders in IBS are limited. We utilized the TriNetX federated research network to evaluate the burden and demographic distribution of psychiatric conditions among adults with IBS. Methods: We conducted a retrospective analysis of de-identified electronic health records from 100 United States healthcare organizations in the TriNetX Research Network from Jan 1, 2015 to Apr 28, 2025. Adults ≥18 years with ≥1 International Classification of Diseases [ICD]-10-CM diagnosis of IBS (K58.0–K58.9) were included. Psychiatric comorbidities were identified using the following ICD-10-CM codes: major depressive disorder (MDD, F32, F33), generalized anxiety disorder (GAD, F41.1), bipolar disorder (BPD, F31), schizophrenia-spectrum disorders (F20–F29), post-traumatic stress disorder (PTSD, F43.1), and obsessive-compulsive disorder (OCD, F42). Outcomes included incidence, prevalence, peak age range, and stratification by sex and race/ethnicity. Results: Among 1,275,194 adults with IBS (mean age 45 ± 17 years; 67% women), the most common psychiatric comorbidities were MDD (prevalence: 38.3%) and GAD (17.9%), followed by PTSD (5.6%), BPD (5.5%), OCD (1.9%), and lastly schizophrenia (0.8%). Women exhibited a greater psychiatric burden across nearly all diagnoses, including MDD (41.6% vs 27.6%), GAD (19.1% vs 13.5%), BPD (5.9% vs 3.9%), OCD (1.93% vs 1.74%) and PTSD (6.2% vs 3.8%). Native Hawaiian/Pacific Islander had the highest prevalence of MDD (51.6%), GAD (61.7%) and American Indian/Alaska Native patients had the highest prevalence of BPD(9.7%), OCD(2.8%) and PTSD (14.8%) whereas Black or African-American population had the highest prevalence of schizophrenia (2.1%). Asian patients consistently had the lowest prevalence across all psychiatric conditions. Conclusion: In this nationwide real-world cohort more than half of adults with IBS carried at least 1 psychiatric diagnosis, most commonly MDD and GAD with markedly higher burdens in women and in several under-represented minority populations. These findings underscore the importance of routine mental-health screening and culturally tailored, integrated care pathways for patients with IBS, particularly for high-risk sex and racial/ethnic groups, to help reduce symptom burden and optimize resource utilization.