Age at type 2 diabetes diagnosis and risk of cancer: Cohort study in over 1 million individuals from the TriNetX US Collaborative Network
The five-year risk of cancer was higher in those with newly diagnosed type 2 diabetes versus those without. Absolute risk was greater in middle-older age adults, although relative rates were greater amongst younger adults. This persisted across most site-specific cancers, suggesting targeted strategies for early detection and prevention may help younger adults with newly-diagnosed type 2 diabetes reduce lifetime disease burden.
Authors
- Joseph J. Henson (ORCID: https://orcid.org/0000-0002-3898-7053)
- Gema Hernández (ORCID: https://orcid.org/0000-0003-4832-455X)
- Dimitris Papamargaritis (ORCID: https://orcid.org/0000-0001-5044-1515)
- Jack A. Sargeant (ORCID: https://orcid.org/0000-0003-0395-7329)
- Thomas E. Yates (ORCID: https://orcid.org/0000-0002-5724-5178)
- Zuzanna Drebert
- Karen Brown (ORCID: https://orcid.org/0000-0002-5217-1501)
- Jonathan Goldney (ORCID: https://orcid.org/0000-0001-8553-8296)
- David R. Webb (ORCID: https://orcid.org/0000-0002-3932-3339)
- Edward W. Gregg (ORCID: https://orcid.org/0000-0003-2381-6822)
- Francesco Zaccardi (ORCID: https://orcid.org/0000-0002-2636-6487)
- Tommy Slater (ORCID: https://orcid.org/0000-0003-2764-3148)
- Melanie Jane Davies (ORCID: https://orcid.org/0000-0002-9987-9371)
- Juliana C.N. Chan (ORCID: https://orcid.org/0000-0003-1325-1194)
Institutions
- Chinese University of Hong Kong (HK)
- Leicester General Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Public Health England (GB)
- TriNetX (United States) (US)
- NIHR Leicester Biomedical Research Centre (GB)
Publication Details
- Journal
- Journal of Diabetes and its Complications
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.jdiacomp.2025.109210
- Citations
- 1
- Primary Topic
- Metabolism, Diabetes, and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81