DCN, NPM3 and SULF1 are hub genes related to vasculogenic mimicry in lung adenocarcinoma
We identified DCN, NPM3, and SULF1 as key biomarkers of VM in LUAD. SULF1, in particular, plays a central role in driving VM formation and tumor progression. These findings offer novel mechanistic insights and highlight potential therapeutic targets for LUAD treatment.
Authors
- Weitao Cao (ORCID: https://orcid.org/0000-0002-1113-603X)
- Zhike Liang
- Shuquan Wei (ORCID: https://orcid.org/0000-0003-4044-2244)
- Zhuxiang Zhao (ORCID: https://orcid.org/0000-0003-3638-298X)
- Jie Zeng (ORCID: https://orcid.org/0000-0001-8809-888X)
- Cheng Sun (ORCID: https://orcid.org/0000-0002-5533-1398)
- Yujun Li (ORCID: https://orcid.org/0000-0002-4737-6975)
- Meifeng Ye
- Ziwen Zhao
Institutions
- Guangzhou First People's Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- South China University of Technology (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1007/s00432-025-06361-0
- Primary Topic
- Angiogenesis and VEGF in Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00