Isonardosinone suppresses osteoclastogenesis through TRAF2/TRAF6-mediated disruption of calcium signaling and coordinate inhibition of MAPK/NF-κB pathways
INS aptly mitigates the process of osteoclastogenesis, leading to a notable enhancement in bone density, effectively exemplifying its pivotal role in the management of OP.
Authors
- Jie Huang (ORCID: https://orcid.org/0000-0003-2168-8556)
- Yang Lv (ORCID: https://orcid.org/0009-0001-7831-3619)
- Jiyao Luan (ORCID: https://orcid.org/0000-0002-8359-2130)
- Chujie Wang (ORCID: https://orcid.org/0000-0001-9336-5663)
- Wei Deng (ORCID: https://orcid.org/0000-0002-1216-549X)
- Jinfang Wang (ORCID: https://orcid.org/0000-0002-3734-7089)
- Zhiteng Tang (ORCID: https://orcid.org/0009-0005-0163-6021)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Zhongshan Hospital (CN)
- Luoyang Orthopedic-Traumatological Hospital of Henan Province (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- BBA Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.bbadva.2025.100173
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00