Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative

At seroconversion, genetically susceptible children who had one or more FDRs with type 1 diabetes, especially an affected father, were more often positive for GADA and multiple islet autoantibodies. During the follow-up period, children with an affected FDR were more often positive for IAA, GADA and IA-2A, and progressed to clinical type 1 diabetes more often and faster than children without an affected FDR. These data should be considered when designing intervention and screening studies.

Authors

Institutions

Publication Details

Journal
Diabetologia
Published
2025-11-08
DOI
https://doi.org/10.1007/s00125-025-06573-6
Primary Topic
Diabetes and associated disorders
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative

Mikael Knip, Riitta Veijola, Jaakko J. Koskenniemi, Taina Härkönen et al.
Diabetologia
Diabetes and associated disorders
article

Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative

Mikael Knip, Riitta Veijola, Jaakko J. Koskenniemi, Taina Härkönen, Tytti Pokka, Jorma Toppari, Johanna Lempainen, Jorma Ilonen, Päivi Keskinen, Salla Kuusela, Anni Kyrönniemi, Toni Valtanen
article en

Abstract

At seroconversion, genetically susceptible children who had one or more FDRs with type 1 diabetes, especially an affected father, were more often positive for GADA and multiple islet autoantibodies. During the follow-up period, children with an affected FDR were more often positive for IAA, GADA and IA-2A, and progressed to clinical type 1 diabetes more often and faster than children without an affected FDR. These data should be considered when designing intervention and screening studies.

DiabetologiaVol. 69(1)
University of Helsinki (FI), University of Turku (FI), Turku Centre for Computer Science (FI), Oulu University Hospital (FI), Helsinki University Hospital (FI), Turku University Hospital (FI), Turku PET Centre (FI), Tampere University Hospital (FI), Tampere University (FI), University of Oulu (FI)
Openalex Percentile: Top 65%
Diabetes and associated disorders
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Islet autoimmunity and progression to type 1 diabetes in the Finnish DIPP study: comparison between genetically susceptible children with and without an affected first-degree relative — Mikael Knip, Riitta Veijola, et al. · Diabetologia (2025) | TGRS Research Map | TGRS