Bile cell-free DNA shows benefit as a potential sample for somatic mutation detection of resectable cholangiocarcinoma
Bile cfDNA outperforms plasma cfDNA in detecting somatic mutations and retains high sensitivity independent of tumor stage, positioning it as a promising tool for early CCA diagnosis and molecular characterization.
Authors
- Xiaowu Ma (ORCID: https://orcid.org/0009-0006-6577-9387)
- Ziyu Zhang (ORCID: https://orcid.org/0000-0002-7142-0518)
- Jian‐Bo Wan (ORCID: https://orcid.org/0000-0002-6750-2617)
- Hongkai Zhuang (ORCID: https://orcid.org/0000-0002-4106-8736)
- Yonglin Hua (ORCID: https://orcid.org/0009-0001-3232-5542)
- Qingbin Wang (ORCID: https://orcid.org/0000-0002-2415-4122)
- Changzhen Shang (ORCID: https://orcid.org/0000-0003-4629-7682)
- Songyao Liu
- Yajin Chen (ORCID: https://orcid.org/0000-0002-4126-0357)
- Yuxin Xiao
- Bingkun Wang (ORCID: https://orcid.org/0000-0003-1636-459X)
Institutions
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- University of Macau (MO)
- Sun Yat-sen Memorial Hospital (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- iLiver
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.iliver.2025.100206
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94