Prognostic evaluation of glycolysis markers in hepatocellular carcinoma: insights from meta-analysis and multi-omics approaches
The upregulation of the glycolysis-related gene signature score is predominantly associated with poor prognosis in patients with HCC, suggesting that GGS may serve as a potential prognostic biomarker and therapeutic target for HCC, as exemplified by ENO1 functional validation.
Authors
- Gangyi Li
- Yongzhi Li (ORCID: https://orcid.org/0000-0002-1765-4807)
- Jie Lin (ORCID: https://orcid.org/0000-0002-2474-5889)
- Shuai Tang (ORCID: https://orcid.org/0000-0003-0261-5001)
- Jiale Zhou (ORCID: https://orcid.org/0000-0002-7643-7984)
- Huaijuan Guo (ORCID: https://orcid.org/0000-0001-7672-0053)
Institutions
- Chengdu Medical College (CN)
- Deyang Stomatological Hospital (CN)
- Neijiang Normal University (CN)
- Northern Jiangsu People's Hospital (CN)
- Second Affiliated Hospital of Jilin University (CN)
- Zigong First People's Hospital (CN)
- Yangzhou University (CN)
Publication Details
- Journal
- BMC Medical Genomics
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1186/s12920-025-02253-x
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- People's Government of Jilin Province
- Education Department of Jilin Province