Role of OCT-4 and NANOG in the Malignant Transformation of Oral Submucous Fibrosis: An Immunohistochemical Evaluation
The elevated expression of OCT-4 and NANOG in OSMF and OSCC+OSMF suggests their involvement in stem cell-driven pathways underlying malignant transformation. These markers may serve as valuable indicators for identifying OSMF patients at higher risk of developing OSCC and hold potential as prognostic and therapeutic indicators in oral carcinogenesis.
Authors
- Diksha Mohapatra (ORCID: https://orcid.org/0009-0000-3446-9550)
Institutions
- Siksha O Anusandhan University (IN)
Publication Details
- Journal
- Cureus
- Published
- 2025-11-07
- DOI
- https://doi.org/10.7759/cureus.96351
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00