Adapting a commercial sample extraction protocol for biosafety level 3/4 compatible plasma metabolomics analysis
This study extends the applicability of commercial metabolomics assays designed for untreated samples by improving their suitability for high-risk infectious disease studies. Differences in metabolite extraction efficiencies and detection rates, as well as data harmonization strategies, should be considered if results from both protocols are to be combined.
Authors
- Vantha Te
- Lisa St. John‐Williams
- Nehkonti Adams (ORCID: https://orcid.org/0000-0002-3122-1207)
- Christopher W. Woods (ORCID: https://orcid.org/0000-0001-7240-2453)
- Joost Brandsma (ORCID: https://orcid.org/0000-0003-2914-3403)
- Ephraim L. Tsalik (ORCID: https://orcid.org/0000-0002-6417-2042)
- Deborah A. Striegel (ORCID: https://orcid.org/0000-0002-1853-3185)
- J. Will Thompson (ORCID: https://orcid.org/0000-0001-6567-1268)
- Subramaniam Krishnan (ORCID: https://orcid.org/0000-0001-5178-1511)
- George Oduro (ORCID: https://orcid.org/0000-0001-5850-7718)
- Josh Chenoweth (ORCID: https://orcid.org/0009-0003-9693-5010)
- M. Arthur Moseley (ORCID: https://orcid.org/0000-0001-9907-738X)
- D.V. Clark (ORCID: https://orcid.org/0000-0003-4463-7217)
- Pavol Genzor (ORCID: https://orcid.org/0000-0002-3316-5659)
- Kevin L. Schully (ORCID: https://orcid.org/0000-0001-5554-0133)
Institutions
- Henry M. Jackson Foundation (US)
- Naval Medical Research Command (US)
- Duke University (US)
- Danaher (United States) (US)
- Komfo Anokye Teaching Hospital (GH)
- United States Army Medical Research and Development Command (US)
- Durham VA Health Care System (US)
Publication Details
- Journal
- Journal of Mass Spectrometry and Advances in the Clinical Lab
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.jmsacl.2025.11.002
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00