Visual versus region-of-interest based diffusion evaluation and their diagnostic impact in adult-type diffuse gliomas
ROI-based diffusion assessment guided by visual input showed superior reproducibility than visual assessment alone. Although visual assessment demonstrated strong correlation with ADC thresholds and comparable overall IDH prediction accuracy, the two methods differ in clinical profile: visual assessment offered high specificity but low sensitivity, whereas ROI-based assessment improved sensitivity at the cost of reduced specificity.
Authors
- Vera C. Keil (ORCID: https://orcid.org/0000-0001-8699-3506)
- Yeva Prysiazhniuk (ORCID: https://orcid.org/0000-0001-7384-1693)
- Ivar J. H. G. Wamelink (ORCID: https://orcid.org/0000-0002-4658-1395)
- Aynur Azizova (ORCID: https://orcid.org/0000-0002-9354-2612)
- Elif Kaya (ORCID: https://orcid.org/0000-0001-6388-9714)
- Frederik Barkhof (ORCID: https://orcid.org/0000-0003-3543-3706)
- Jan Petr (ORCID: https://orcid.org/0000-0002-3201-6002)
- Marcus Cakmak
Institutions
- Charles University (CZ)
- Dutch Cancer Society (NL)
- Helmholtz-Zentrum Dresden-Rossendorf (DE)
- University Hospital in Motol (CZ)
- Amsterdam Neuroscience (NL)
- Ankara Yıldırım Beyazıt University (TR)
- National Hospital for Neurology and Neurosurgery (GB)
- Cancer Center Amsterdam (NL)
- University College London (GB)
- Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Neuroradiology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1007/s00234-025-03832-6
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University College London
- Agentura Pro Zdravotnický Výzkum České Republiky