Integrative Multiomics Analysis Identifies HK2 as a Key Regulator of Metabolic Reprogramming in Hepatic Stellate Cells
HK2 is involved in activating HSCs, thus promoting the progression of liver fibrosis. These findings suggest that HK2 holds potential as a therapeutic target for liver fibrosis and as a biomarker for predicting its progression.
Authors
- Xueke Zhao (ORCID: https://orcid.org/0000-0002-3032-4933)
- Hongfei Pu (ORCID: https://orcid.org/0009-0009-7945-7962)
- Qingxiu Zhang (ORCID: https://orcid.org/0009-0001-0788-7228)
- Huayue Wu (ORCID: https://orcid.org/0009-0000-1407-4981)
- Shaojie Chen (ORCID: https://orcid.org/0009-0005-5446-8973)
- Jinglin Wang (ORCID: https://orcid.org/0000-0002-7389-1022)
- Chen Pan (ORCID: https://orcid.org/0000-0002-3144-3854)
- Tao Huang (ORCID: https://orcid.org/0000-0001-6849-5378)
- Fan Lü (ORCID: https://orcid.org/0009-0002-5022-7767)
- Lu Han (ORCID: https://orcid.org/0000-0002-9198-6455)
- Gao-Liang Zou (ORCID: https://orcid.org/0000-0002-9460-0802)
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
- Guizhou Provincial People's Hospital (CN)
Publication Details
- Journal
- Human Mutation
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1155/humu/1584910
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guizhou Medical University