M2a macrophages identified as a potential therapeutic candidate for intervertebral disc herniation regression
M2a macrophages showed the highest potential towards the design of a macrophage-based therapy for LDH. This study holds great promise for translational medicine aimed at accelerating spontaneous LDH using a physiological treatment that could prevent need for surgical intervention.
Authors
- Carla Cunha (ORCID: https://orcid.org/0000-0002-9096-5644)
- Hans-Joerg Meisel (ORCID: https://orcid.org/0000-0003-3838-1489)
- Paulo Pereira (ORCID: https://orcid.org/0000-0001-6961-9213)
- Mário A. Barbosa (ORCID: https://orcid.org/0000-0003-3568-7482)
- Tiago Castanheira (ORCID: https://orcid.org/0009-0002-6875-5197)
- Pedro Santos Silva (ORCID: https://orcid.org/0000-0002-7523-5782)
- Zorica Buser (ORCID: https://orcid.org/0000-0002-5680-0643)
- Michael C. Gerling (ORCID: https://orcid.org/0000-0003-3985-7119)
- Gabriel Courties (ORCID: https://orcid.org/0000-0002-0003-7407)
- Catarina Correia (ORCID: https://orcid.org/0000-0003-3055-1674)
- Melissa Baker (ORCID: https://orcid.org/0009-0001-0869-8330)
- Catarina Meireles
Institutions
- Inserm (FR)
- Universidade do Porto (PT)
- Université de Montpellier (FR)
- Hospital de São João (PT)
- Institute for Regenerative Medicine & Biotherapy (FR)
- New York Proton Center (US)
- CUF Porto Hospital (PT)
- BG Klinikum Bergmannstrost Halle (DE)
- i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto (PT)
- New York University (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100701
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00