Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach
Our findings highlight that hub genes like <i>EZH2</i> and <i>PTEN</i> are potential biomarkers and therapeutic targets for modulating ferroptosis in breast cancer. These results provide a strong foundation for future experimental validation to translate computational insights into clinical applications.
Authors
- Javad Yaghmoorian Khojini (ORCID: https://orcid.org/0000-0003-3445-7984)
- Hamed Manoochehri (ORCID: https://orcid.org/0000-0002-7117-1857)
- Mohammad Javad Mousavi (ORCID: https://orcid.org/0000-0003-4849-6706)
- Mohammad Javad Hayati (ORCID: https://orcid.org/0009-0004-6367-793X)
- Akram Heydari
- Fatemeh Khara
- Seyed Mohammad Sadra Abootorabi
Institutions
- Biotechnology Research Center (IR)
- Bushehr University of Medical Sciences (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Biochemistry and Biophysics Reports
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.bbrep.2025.102335
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00