Inverse correlation between Lamin A/C and survival in ovarian cancer: implications for predicting responsiveness to taxane-based chemotherapy
A significant correlation was found between Lamin A/C expression and OS, which implies that strong, widespread Lamin A/C expression in primary tumor tissues may be a predictive marker for paclitaxel sensitivity and thus survival, supporting a proposed paclitaxel mechanism in inducing micronucleation of cancer cells.
Authors
- Sophia H.L. George (ORCID: https://orcid.org/0000-0003-1013-1883)
- Xiang‐Xi Xu (ORCID: https://orcid.org/0000-0003-2886-5308)
- Ie−Ming Shih (ORCID: https://orcid.org/0000-0002-1084-2071)
- Tian‐Li Wang (ORCID: https://orcid.org/0000-0002-7082-449X)
- Kathy Q. Cai (ORCID: https://orcid.org/0000-0002-6034-3377)
- Matthew Schlumbrecht (ORCID: https://orcid.org/0000-0002-0257-7327)
- Elizabeth R. Smith
- Isaac Xu
Institutions
- Fox Chase Cancer Center (US)
- University of Miami (US)
- Dr. John T. Macdonald Foundation (US)
- Johns Hopkins Hospital (US)
- Sylvester Comprehensive Cancer Center (US)
Publication Details
- Journal
- Gynecologic Oncology Reports
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.gore.2025.101978
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00