Vasorelaxant effects of the edible flowers <i>Tagetes erecta</i> L. and its possible mechanism of action
The extracts induced concentration-dependent vasorelaxation though both endothelium-dependent and -independent mechanisms. At low concentrations, relaxation was mediated by nitric oxide, while at higher concentrations it involved inhibition of intracellular Ca<sup>2+</sup>, opening of K<sup>+</sup> channels, and activation of protein kinase A. In <i>C. elegans</i>, the extracts significantly reduced pharyngeal pumping. This study is the first to suggest that <i>T. erecta</i> could be beneficial in treating pathologies associated with endothelial dysfunction, such as hypertension.
Authors
- Marta Sofía Valero (ORCID: https://orcid.org/0000-0002-2231-7565)
- Víctor López (ORCID: https://orcid.org/0000-0001-6969-1055)
- Miguel Ángel Plaza (ORCID: https://orcid.org/0000-0002-7412-2073)
- María Pilar Arruebo (ORCID: https://orcid.org/0000-0002-2114-0577)
- Sonia Núñez (ORCID: https://orcid.org/0000-0003-4986-5286)
- Carlota Gómez‐Rincón (ORCID: https://orcid.org/0000-0003-3982-2282)
Institutions
- Universidad de Zaragoza (ES)
- Universidad San Jorge (ES)
- Centro de Investigación y Tecnología Agroalimentaria de Aragón (ES)
Publication Details
- Journal
- Pharmaceutical Biology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1080/13880209.2025.2583836
- Primary Topic
- Medicinal Plant Extracts Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Universidad San Jorge
- Ministerio de Ciencia e Innovación
- Universidad de Zaragoza
- Gobierno de Aragón