Extending the ALPS index: Associating whole-brain patterns with glymphatic-related diffusion metrics in multiple sclerosis
The proposed GAM method evidenced widespread associations of GS impairment and tissue damage in MS. The overlap of GAM in basal ganglia and thalamus in MS can serve as mechanistic corroboration of previous pathological findings in these areas.
Authors
- Gabriel González‐Escamilla (ORCID: https://orcid.org/0000-0002-7209-1736)
- Sergiu Groppa (ORCID: https://orcid.org/0000-0002-2551-5655)
- Sascha D. Santaniello (ORCID: https://orcid.org/0009-0002-1930-7443)
- Andrea Kronfeld (ORCID: https://orcid.org/0000-0003-1814-5649)
- Markus Janko (ORCID: https://orcid.org/0000-0002-6123-0518)
- Ahmed E. Othman (ORCID: https://orcid.org/0000-0002-3827-8695)
- Marc Alexander Brockmann (ORCID: https://orcid.org/0000-0002-4514-4468)
Institutions
- Johannes Gutenberg University Mainz (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.msard.2025.106835
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00