The nitrite reductase activity of xanthine oxidoreductase sustains cardiovascular health as mice age
In summary, XOR derived NO is critical for maintaining, during ageing, vascular homeostasis under physiological conditions and is key in mediating the benefits of dietary nitrate regimes in cardiovascular pathology.
Authors
- Jonathan Ho (ORCID: https://orcid.org/0000-0001-9299-9824)
- Krishnaraj Sinhji Rathod (ORCID: https://orcid.org/0000-0003-4268-5055)
- Umme Siddique
- D. Matthew Sullivan (ORCID: https://orcid.org/0000-0001-5537-6986)
- Amrita Ahluwalia (ORCID: https://orcid.org/0000-0001-7626-6399)
- Gianmichele Massimo (ORCID: https://orcid.org/0000-0001-9461-9629)
- Tipparat Parakaw (ORCID: https://orcid.org/0000-0003-4679-9279)
- Lorna C. Gee
- Nicki Dyson
- Claudia Cabrera (ORCID: https://orcid.org/0000-0002-2205-5315)
- Rayomand S. Khambata (ORCID: https://orcid.org/0000-0001-6144-421X)
- A Noor (ORCID: https://orcid.org/0000-0003-4015-7224)
- Indra A. Lim
- Michael R. Barnes (ORCID: https://orcid.org/0000-0001-9097-7381)
- Ngan HH. Khuat
Institutions
- Queen Mary University of London (GB)
Publication Details
- Journal
- Redox Biology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.redox.2025.103923
- Citations
- 1
- Primary Topic
- Nitric Oxide and Endothelin Effects
- Type
- article
- Field-Weighted Citation Impact
- 1.16