Pharmacokinetic-guided dose reduction of emicizumab in congenital hemophilia A: interim analysis of the DosEmi study
These interim results suggest that bleeding control with PK-guided reduced emicizumab dosing (target Ctrough 25-35 μg/mL) is similar to conventional dosing. All prespecified criteria for study continuation and inclusion of participants aged <16 years were met.
Authors
- Michiel Coppens (ORCID: https://orcid.org/0000-0001-6891-9062)
- Frank W.G. Leebeek (ORCID: https://orcid.org/0000-0001-5677-1371)
- M.H.E. Driessens (ORCID: https://orcid.org/0000-0001-7423-8538)
- Paul L. den Exter (ORCID: https://orcid.org/0000-0002-1543-5731)
- Anouk A. M. T. Donners (ORCID: https://orcid.org/0000-0002-8147-013X)
- Rolf T. Urbanus (ORCID: https://orcid.org/0000-0002-1601-9393)
- Alexander Janßen (ORCID: https://orcid.org/0000-0003-0719-0831)
- Jeroen C.J. Eikenboom (ORCID: https://orcid.org/0000-0002-3268-5759)
- J. Lock
- Ron A. A. Mathôt (ORCID: https://orcid.org/0000-0001-8401-0879)
- Tim Preijers (ORCID: https://orcid.org/0000-0001-6953-0358)
- Iris van Moort (ORCID: https://orcid.org/0000-0002-0248-4710)
- Marieke J. H. A. Kruip (ORCID: https://orcid.org/0000-0002-0265-4871)
- Ineke van Vliet
- Dan Hart
- Paula F. Ypma (ORCID: https://orcid.org/0000-0003-1250-7979)
- Kathelijn Fischer (ORCID: https://orcid.org/0000-0001-7126-6613)
- M.C.H.J. Goedhart
- Marjon H. Cnossen (ORCID: https://orcid.org/0000-0003-1557-2995)
- Konrad van der Zwet (ORCID: https://orcid.org/0000-0001-9082-1416)
- F.J.M. van der Meer (ORCID: https://orcid.org/0000-0002-0221-9618)
- H.C.A.M. Hazendonk (ORCID: https://orcid.org/0000-0003-4988-0582)
- Allert H. Vos (ORCID: https://orcid.org/0009-0002-4028-8371)
- Karin P. M. van Galen (ORCID: https://orcid.org/0000-0003-3251-8595)
- Jessica M. Heijdra (ORCID: https://orcid.org/0000-0003-1069-8097)
- Saskia E.M. Schols (ORCID: https://orcid.org/0000-0003-2423-2829)
- Michael E. Cloesmeijer (ORCID: https://orcid.org/0000-0002-2810-1570)
- Ri Liesner (ORCID: https://orcid.org/0000-0001-5659-554X)
- Laurens Nieuwenhuizen (ORCID: https://orcid.org/0000-0002-0494-9374)
- Roger E. G. Schutgens (ORCID: https://orcid.org/0000-0002-2762-6033)
- Nico C. B. de Jager (ORCID: https://orcid.org/0000-0002-3512-1633)
- Hélène L. Hooimeijer (ORCID: https://orcid.org/0000-0002-5522-2896)
- Laura H. Bukkems (ORCID: https://orcid.org/0000-0001-7967-1023)
- Karina Meijer (ORCID: https://orcid.org/0000-0001-9447-0465)
- Floor Heubel-Moenen (ORCID: https://orcid.org/0000-0002-3281-926X)
- Wala Al Arashi (ORCID: https://orcid.org/0000-0003-4218-8550)
- R. Y. J. Tamminga (ORCID: https://orcid.org/0000-0001-7986-7712)
- Ilmar C. Kruis (ORCID: https://orcid.org/0000-0003-4118-4670)
- Lize F. D. van Vulpen (ORCID: https://orcid.org/0000-0003-3242-5524)
- Karin Fijnvandraat (ORCID: https://orcid.org/0000-0003-0904-4360)
- Carolyn M. Millar
- David Keeling
- Paul Brons
- Suzanne Polinder
- Peter W. Collins
- Pratima Chowdary
- Corien L. Eckhardt (ORCID: https://orcid.org/0009-0007-0025-6961)
- Erik E.A.M. Beckers
Institutions
- University Medical Center Groningen (NL)
- Radboud University Nijmegen (NL)
- Utrecht University (NL)
- Dutch Cancer Society (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Amsterdam Neuroscience (NL)
- Erasmus MC - Sophia Children’s Hospital (NL)
- Haga Hospital (NL)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- Journal of Thrombosis and Haemostasis
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.jtha.2025.10.029
- Citations
- 2
- Primary Topic
- Hemophilia Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 3.54
Funders
- Amsterdam University Medical Centers
- Maastricht Universitair Medisch Centrum