Baicalein ameliorates high-altitude hypoxic lung injury via macrophage polarization remodeling by downregulating ALOX15 pathway in ferroptosis
ALOX15 could exacerbates high-altitude hypoxic ALI inflammatory responses by promoting both macrophage ferroptosis and M1 polarization. Identification of baicalein as an ALOX15 inhibitor mitigates ferroptosis, shifts macrophages to the M2 phenotype, and reduces inflammation, offering a promising preventative strategy for high-altitude hypoxic lung injury.
Authors
- Shou-Hou Liu (ORCID: https://orcid.org/0009-0003-6605-2698)
- Mianyang Li (ORCID: https://orcid.org/0009-0000-6093-4890)
- Yujie Wei (ORCID: https://orcid.org/0000-0002-3213-7891)
- Chi Chiu Wang (ORCID: https://orcid.org/0000-0002-3928-7278)
- Qi Wang (ORCID: https://orcid.org/0000-0002-5287-6050)
- Ting Liu (ORCID: https://orcid.org/0000-0003-1816-5551)
- Chengbin Wang (ORCID: https://orcid.org/0000-0002-6535-5967)
- Wei Yan (ORCID: https://orcid.org/0000-0002-6972-7393)
- Liye Wang
- Haoran Guo (ORCID: https://orcid.org/0000-0001-8244-5545)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.intimp.2025.115767
- Citations
- 2
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04