Multiomics insights into retinoic acid–mediated regulation of eosinophils in severe asthma
These findings highlight the role of ATRA in maintaining eosinophil homeostasis and counterregulating IL-5-driven activation, thus offering insights into potential therapeutic strategies for severe asthma.
Authors
- Yoshinori Hasegawa (ORCID: https://orcid.org/0000-0003-2904-6611)
- Shinichi Okuzumi
- Yo Otsu (ORCID: https://orcid.org/0000-0003-2828-5063)
- Keeya Sunata (ORCID: https://orcid.org/0000-0002-1694-8432)
- Yusuke Kawashima (ORCID: https://orcid.org/0000-0002-9779-8199)
- M. Ishikawa (ORCID: https://orcid.org/0000-0002-3101-6713)
- Yoshifumi Kimizuka (ORCID: https://orcid.org/0000-0002-4026-7506)
- Katsunori Masaki (ORCID: https://orcid.org/0000-0003-0909-9409)
- Ryo Konno (ORCID: https://orcid.org/0000-0002-4375-1133)
- Emiko Matsuyama (ORCID: https://orcid.org/0000-0002-9822-6184)
- Hiroki Kabata (ORCID: https://orcid.org/0000-0001-8853-6149)
- Hisashi Sasaki (ORCID: https://orcid.org/0000-0001-7642-2451)
- Jun Miyata (ORCID: https://orcid.org/0000-0002-3189-1702)
- Makoto Arita (ORCID: https://orcid.org/0000-0001-9902-0463)
- Koichi Fukunaga (ORCID: https://orcid.org/0000-0001-7460-1990)
- Takao Mochimaru (ORCID: https://orcid.org/0000-0002-1505-6651)
- Ryuta Onozato
Institutions
- Keio University (JP)
- Kazusa DNA Research Institute (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- National Defense Medical College (JP)
- Yokohama City University (JP)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-11-08
- DOI
- https://doi.org/10.1016/j.jaci.2025.10.029
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00