Gene Signature Associated with Ferroptosis for Predicting Overall Survival among Ovarian Cancer Patients
Distinct from apoptosis, ferroptosis is intricately associated with intracellular iron ions and oxidative stress, representing a unique form of cell demise. In the treatment of ovarian cancer (OC), it assumes a crucial role, as research suggests its association with patient prognosis. This investigation delves into the correlation between genes associated with ferroptosis and the prognosis of OC, providing insights into its pathogenesis. Through the examination of mRNA expression using TCGA, ICGC, and GTEx databases, we identified a set of five pivotal genes (CD44, FTH1, ALOX12, SLC7A11, CRYAB) forming a prognostic model. Their regulation affects various aspects of OC, including the cell cycle, proliferation, invasiveness, immune response, and drug tolerance. To summarize, ferroptosis significantly impacts the prognosis of OC, and the targeting of relevant pathways holds potential for enhancing treatment outcomes, thereby guiding future research and personalized therapeutic strategies.
Authors
- Jingman Tang
- Jianhong Lu (ORCID: https://orcid.org/0000-0002-4436-1217)
- Kaixiang Li (ORCID: https://orcid.org/0000-0002-3110-1010)
- Yan Liu (ORCID: https://orcid.org/0000-0003-2918-5398)
- Yanling Li (ORCID: https://orcid.org/0000-0002-9700-8978)
- Lu Xu (ORCID: https://orcid.org/0000-0001-8447-135X)
- Yidi Wang (ORCID: https://orcid.org/0000-0002-2400-8109)
- Yulong Peng (ORCID: https://orcid.org/0000-0002-8710-400X)
- Lili Fan (ORCID: https://orcid.org/0000-0002-1318-7017)
- Jianbo He (ORCID: https://orcid.org/0000-0002-0623-9763)
- Lei Han (ORCID: https://orcid.org/0009-0000-9840-4692)
- Xiaojuan Li
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Central South University (CN)
- Jinan University (CN)
- Hunan Cancer Hospital (CN)
- Xiangya Hospital Central South University (CN)
- First Affiliated Hospital of Jinan University (CN)
Publication Details
- Journal
- Journal of Cancer
- Published
- 2025-10-20
- DOI
- https://doi.org/10.7150/jca.116777
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Guangdong Provincial Hospital of Traditional Chinese Medicine
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- K. C. Wong Education Foundation
- Basic and Applied Basic Research Foundation of Guangdong Province