Association of different autoimmune diseases with gastric cancer incidence and risk: a global population-based analysis

Autoimmune diseases were associated with increased gastric cancer risk, especially autoimmune gastritis, systemic sclerosis, type 1 diabetes, sarcoidosis, and psoriasis. Patients with dermatomyositis and systemic lupus erythematosus were potentially associated with an elevated risk of gastric cancer. Surprisingly, ulcerative colitis had a protective effect against gastric cancer, especially among East Asian countries. Regarding sex analysis, male and female patients were similarly susceptible to autoimmunity-induced gastric carcinogenesis. As for geographical differences, patients with autoimmune diseases from Nordic countries were most likely to have an increased risk of gastric cancer, while autoimmune diseases seemed to have protective effects against gastric cancer among Japanese patients, especially those with rheumatoid arthritis.