Endothelial circadian rhythm genes as prognostic modulators of tumor progression and immune interactions: insights from pan-cancer single-cell RNA sequencing
Endothelial circadian rhythm genes play a significant role in regulating tumor progression, immune interactions, and patient prognosis. Dysregulation of the ENDO.CIRCADIAN.RHYTHM.SIG gene set correlates with adverse clinical outcomes and may serve as a potential prognostic biomarker and therapeutic target. Our findings suggest that targeting circadian rhythm pathways within the TME could enhance personalized cancer treatment strategies.
Authors
- Yangyang Li (ORCID: https://orcid.org/0000-0002-5791-9443)
- Yong Wang (ORCID: https://orcid.org/0000-0001-7682-0433)
- Jie Liu (ORCID: https://orcid.org/0000-0003-2046-3021)
- Hao Qin (ORCID: https://orcid.org/0000-0001-8915-6359)
- Yalan Xu (ORCID: https://orcid.org/0000-0001-8993-4464)
- Yi-Fang Yan
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- Peking Union Medical College Hospital (CN)
- China Rehabilitation Research Center (CN)
- Ministry of Education (ME)
- Peking University Third Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1097/js9.0000000000003848
- Citations
- 1
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 0.91