Trajectory of olfactory cortex degeneration from normal cognition to Alzheimer's disease: Insights from multimodal neuroimaging
Our findings delineate a spatiotemporal progression of olfactory cortex degeneration, with early POC alterations in MCI evolving into widespread atrophy and functional dysregulation in AD. Multimodal MRI metrics and logistic modeling yield highly accurate stage classification, underscoring their potential as sensitive biomarkers for early AD detection and monitoring.
Authors
- Dan Liao (ORCID: https://orcid.org/0000-0001-7892-5060)
- Huimao Zhang (ORCID: https://orcid.org/0000-0003-0443-2831)
- Chunjie Guo (ORCID: https://orcid.org/0000-0002-5784-0479)
- Zhuo Wang (ORCID: https://orcid.org/0000-0002-6382-1717)
- Yang Yu
- Yuejiao Sun
- Simin Yang
- Bo Xie
Institutions
- Jilin University (CN)
- First Hospital of Jilin University (CN)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1016/j.nbd.2025.107181
- Citations
- 1
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.46