The Aging Microenvironment Is a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer
Age-dependent stromal changes drive progression of pancreatic cancer, linking aging, stromal remodeling, and tumor aggressiveness and suggesting that rejuvenating the aged microenvironment may improve outcomes in older patients.
Authors
- Weiliang Huang (ORCID: https://orcid.org/0000-0002-9608-2172)
- Priyanka Gupta (ORCID: https://orcid.org/0000-0002-7695-4527)
- Cheska Marie Galapate (ORCID: https://orcid.org/0000-0002-7995-1663)
- Rabi Murad (ORCID: https://orcid.org/0009-0004-5297-8307)
- Swetha Maganti (ORCID: https://orcid.org/0009-0002-0494-3033)
- Yijuan Zhang (ORCID: https://orcid.org/0000-0002-1392-1816)
- Li Ling (ORCID: https://orcid.org/0009-0005-2908-3609)
- Marzia Scortegagna (ORCID: https://orcid.org/0009-0006-0788-3194)
- Cosimo Commisso (ORCID: https://orcid.org/0000-0002-7884-9210)
- Karen Duong‐Polk (ORCID: https://orcid.org/0009-0007-0471-1458)
Institutions
- Sanford Burnham Prebys Medical Discovery Institute (US)
- Discovery Institute (US)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1158/0008-5472.can-25-1904
- Citations
- 1
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.05