Parkinson Disease <i>SNCA</i> Risk Variants Are Associated With Higher Asymmetric Putamen Dopaminergic Dysfunction
Our findings suggest that a more lateralized putaminal dopaminergic degeneration in early PD may represent a viable endophenotype in carriers of <i>SNCA</i> risk variants, emphasizing the relevant role of neuroimaging in PD subtyping and biomarker identification.
Authors
- Mostafa Kandil (ORCID: https://orcid.org/0009-0005-3593-2136)
- Alain Dagher (ORCID: https://orcid.org/0000-0002-0945-5779)
- Lynne Krohn (ORCID: https://orcid.org/0000-0001-6554-1666)
- Saud Alhusaini (ORCID: https://orcid.org/0000-0002-6869-3830)
- Janine Bacic (ORCID: https://orcid.org/0000-0002-6258-3913)
- Ziv Gan‐Or (ORCID: https://orcid.org/0000-0003-0332-234X)
- Gabriel Dayanim (ORCID: https://orcid.org/0009-0009-3593-1132)
Institutions
- Brown University (US)
- University of Alabama at Birmingham (US)
- McGill Genome Centre (CA)
- McGill University (CA)
Publication Details
- Journal
- Neurology Genetics
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1212/nxg.0000000000200327
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00