In-Depth Analysis of the Paramagnetic Properties in DHI/DHICA-Controlled Eumelanin
Eumelanin, a naturally occurring pigment derived from the oxidative polymerization of 5,6-dihydroxyindole (DHI) and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), has been extensively studied for its role in human biology and its potential applications in biomedical and sustainable electronic fields. By employing X-band electron paramagnetic resonance spectroscopy, this study focuses on eumelanin with different DHI/DHICA ratios, directly comparing monomeric and polymeric forms. The analysis reveals significant differences in the paramagnetic profiles, with changes in spin dynamics and relaxation times closely linked to the distinct macrostructures formed during polymerization. These findings offer valuable insights into how the molecular architecture of eumelanin influences its paramagnetic environments.
Authors
- Alessandro Pezzella (ORCID: https://orcid.org/0000-0001-6925-922X)
- Carlos F. O. Graeff (ORCID: https://orcid.org/0000-0003-0162-8273)
- João Vitor Paulin (ORCID: https://orcid.org/0000-0002-2379-6203)
- João P. Cachaneski-Lopes (ORCID: https://orcid.org/0000-0002-6672-4170)
- Augusto Batagin‐Neto (ORCID: https://orcid.org/0000-0003-4609-9002)
- Emanuele Carrella
Institutions
- Dr Emilio B Espinosa Sr Memorial State College of Agriculture and Technology (PH)
- Federico II University Hospital (IT)
- Institute of Engineering Science (RU)
- National Institute of Meteorology (TN)
- National Interuniversity Consortium of Materials Science and Technology (IT)
- Institute of Polymers, Composites and Biomaterials (IT)
- BioElectronics (United States) (US)
- University of Naples Federico II (IT)
- Universidade Estadual Paulista (Unesp) (BR)
Publication Details
- Journal
- ACS Omega
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1021/acsomega.5c08896
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00