Escin inhibits PD-L1 expression by suppressing the p38 MAPK/ERK signalling pathways and synergistically enhances PD-1 inhibitor efficacy in hepatocellular carcinoma
This study provides novel insights into the mechanism of action of escin in inhibiting HCC and confirms the potential of escin in conjunction with ICIs as a therapeutic approach to impede HCC progression.
Authors
- Suvash Chandra Ojha (ORCID: https://orcid.org/0000-0003-1289-2985)
- Jintao Gu (ORCID: https://orcid.org/0000-0001-8485-0202)
- Changfeng Sun (ORCID: https://orcid.org/0000-0001-8648-8120)
- Xiaochang Xue (ORCID: https://orcid.org/0000-0001-9875-9821)
- Shirong Chen (ORCID: https://orcid.org/0000-0002-2159-8844)
- Zenglu Wang (ORCID: https://orcid.org/0000-0001-9512-8960)
- Zhigang Cao (ORCID: https://orcid.org/0009-0003-5281-9499)
- Yue Yuan (ORCID: https://orcid.org/0009-0006-0638-9266)
- Wang Gan (ORCID: https://orcid.org/0000-0002-4981-8845)
- Jiefang Kang (ORCID: https://orcid.org/0000-0003-2809-3934)
- Ping Wang (ORCID: https://orcid.org/0000-0001-9638-742X)
Institutions
- Northwest University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Shaanxi Normal University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1016/j.phymed.2025.157532
- Citations
- 1
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.81