Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes
In the CKD-PC, 11% of outpatient participants and 35% of hospitalized patients had an eGFRcys that was at least 30% lower than their eGFRcr. In the outpatient setting, presence of eGFRcys at least 30% lower than eGFRcr was associated with significantly higher rates of all-cause mortality, cardiovascular events, and kidney failure.
Authors
- Ron T. Gansevoort (ORCID: https://orcid.org/0000-0002-3223-0906)
- Lyanne M. Kieneker (ORCID: https://orcid.org/0000-0002-8028-6488)
- Narayan Prasad (ORCID: https://orcid.org/0000-0001-9801-0474)
- Dorothea Nitsch (ORCID: https://orcid.org/0000-0001-5767-248X)
- Ben Schöttker (ORCID: https://orcid.org/0000-0002-1217-4521)
- Chi‐yuan Hsu (ORCID: https://orcid.org/0000-0001-8182-1238)
- Kevan R. Polkinghorne (ORCID: https://orcid.org/0000-0002-9851-002X)
- Vivek Kumar (ORCID: https://orcid.org/0000-0001-5271-3668)
- Markus P. Schneider (ORCID: https://orcid.org/0000-0002-5265-8088)
- Anne‐Laure Faucon (ORCID: https://orcid.org/0000-0001-6716-1157)
- Vilmantas Giedraitis (ORCID: https://orcid.org/0000-0003-3423-2021)
- Ulla T. Schultheiß (ORCID: https://orcid.org/0000-0002-7541-5310)
- Mary Cushman (ORCID: https://orcid.org/0000-0002-7871-6143)
- Joachim H. Ix (ORCID: https://orcid.org/0000-0002-8084-9869)
- Antoine Créon (ORCID: https://orcid.org/0009-0006-6498-0257)
- Edouard L. Fu (ORCID: https://orcid.org/0000-0002-9698-6825)
- Jonathan Emberson (ORCID: https://orcid.org/0000-0001-7792-9422)
- Tsuneo Konta (ORCID: https://orcid.org/0000-0001-7681-6469)
- Andrew S. Levey (ORCID: https://orcid.org/0000-0003-1491-501X)
- Morgan E. Grams (ORCID: https://orcid.org/0000-0002-4430-6023)
- Robin W.M. Vernooij (ORCID: https://orcid.org/0000-0001-5734-4566)
- Aditya Surapaneni (ORCID: https://orcid.org/0000-0003-4978-5980)
- Manisha Sahay (ORCID: https://orcid.org/0000-0001-5534-2516)
- Katharine L. Cheung (ORCID: https://orcid.org/0000-0002-2282-4778)
- John Townend (ORCID: https://orcid.org/0000-0002-5881-5806)
- Stephan J. L. Bakker (ORCID: https://orcid.org/0000-0003-3356-6791)
- Ron T. Gansevoort
- Michelle M. Estrella (ORCID: https://orcid.org/0000-0002-8902-9576)
- Orlando M. Gutiérrez (ORCID: https://orcid.org/0000-0001-6593-3571)
- Patrick Barry Mark (ORCID: https://orcid.org/0000-0003-3387-2123)
- Josef Coresh (ORCID: https://orcid.org/0000-0002-4598-0669)
- Teresa K. Chen (ORCID: https://orcid.org/0000-0003-0106-050X)
- Angela Yee‐Moon Wang (ORCID: https://orcid.org/0000-0003-2508-7117)
- Debbie L. Cohen (ORCID: https://orcid.org/0000-0002-1325-315X)
- Hannah Stocker (ORCID: https://orcid.org/0000-0001-5281-2455)
- Juan Jesús Carrero (ORCID: https://orcid.org/0000-0003-4763-2024)
- Lesley A. Inker (ORCID: https://orcid.org/0000-0003-2820-9482)
- Satoru Nagase (ORCID: https://orcid.org/0000-0001-5212-1128)
- Martin Larson
- Johan Ärnlöv
- Bénédicte Stengel (ORCID: https://orcid.org/0000-0001-9469-0804)
- Junta Tanaka (ORCID: https://orcid.org/0000-0001-9907-8147)
- Kai‐Uwe Eckardt (ORCID: https://orcid.org/0000-0003-3823-0920)
- Jennifer Susan Lees (ORCID: https://orcid.org/0000-0001-6331-0178)
- Keiko Kabasawa (ORCID: https://orcid.org/0000-0002-3665-9996)
- Anna Köttgen (ORCID: https://orcid.org/0000-0002-4671-3714)
- Michael G. Shlipak (ORCID: https://orcid.org/0000-0002-9559-204X)
- Marco van Londen (ORCID: https://orcid.org/0000-0001-7145-3240)
- Steven J. Chadban (ORCID: https://orcid.org/0000-0002-0527-898X)
- Daniel A Levy (ORCID: https://orcid.org/0000-0003-1843-8724)
- Yingying Sang (ORCID: https://orcid.org/0000-0002-6179-7864)
- Mark J. Sarnak (ORCID: https://orcid.org/0000-0002-2457-6368)
- Hermann Brenner (ORCID: https://orcid.org/0000-0002-6129-1572)
- Titilayo O. Ilori (ORCID: https://orcid.org/0000-0002-7457-0618)
- Ashok K. Yadav (ORCID: https://orcid.org/0000-0003-2716-0971)
- Shoshana H. Ballew (ORCID: https://orcid.org/0000-0002-7547-3764)
- Marie-Hélène Metzger (ORCID: https://orcid.org/0000-0001-8961-0398)
- Peggy Sekula (ORCID: https://orcid.org/0000-0003-2263-447X)
- Ichiei Narita
- Dietrich Rothenbacher (ORCID: https://orcid.org/0000-0002-3563-2791)
- Nisha Bansal (ORCID: https://orcid.org/0000-0002-9583-8628)
- Carina Flaherty (ORCID: https://orcid.org/0000-0002-2738-4273)
- Amanda Anderson (ORCID: https://orcid.org/0000-0001-8247-4821)
- Aurora Caldinelli (ORCID: https://orcid.org/0009-0009-6019-9342)
- Wei Peter Yang (ORCID: https://orcid.org/0000-0001-8984-4389)
- Shih‐Jen Hwang (ORCID: https://orcid.org/0000-0002-2129-5704)
- Yumi Ito (ORCID: https://orcid.org/0000-0001-8189-105X)
- Masafumi Watanabe (ORCID: https://orcid.org/0000-0002-8672-7483)
- Yingying Sang
- David C. Wheeler
- Martin Landray
- Anders Larsson
- Kevan Polkinghorne
- Natalia Alencar de Pinho
- Kunihiro Matsushita
- Kazunobu Ichikawa (ORCID: https://orcid.org/0009-0004-7869-4716)
Institutions
- University of Vermont (US)
- Yamagata University (JP)
- Dalarna University (SE)
- Tufts Medical Center (US)
- National Institutes of Health (US)
- University Medical Center Groningen (NL)
- Inserm (FR)
- University of Groningen (NL)
- German Cancer Research Center (DE)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Utrecht University (NL)
- Heidelberg University (DE)
- Université Paris-Saclay (FR)
- UC San Diego Health System (US)
- Kidney Research UK (GB)
- Monash Medical Centre (AU)
- Karolinska Institutet (SE)
- University Medical Center Utrecht (NL)
- University of California San Diego (US)
- Universitätsklinikum Erlangen (DE)
- VA San Diego Healthcare System (US)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- National Heart, Lung, and Blood Institute (US)
- Monash Health (AU)
- San Francisco VA Health Care System (US)
- Queen Elizabeth University Hospital (GB)
- University College London (GB)
- Post Graduate Institute of Medical Education and Research (IN)
- Monash University (AU)
- New York University (US)
- Niigata University (JP)
- Charité - Universitätsmedizin Berlin (DE)
- University of Glasgow (GB)
- University of Pennsylvania (US)
Publication Details
- Journal
- JAMA
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1001/jama.2025.17578
- Citations
- 3
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 4.29