Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes

In the CKD-PC, 11% of outpatient participants and 35% of hospitalized patients had an eGFRcys that was at least 30% lower than their eGFRcr. In the outpatient setting, presence of eGFRcys at least 30% lower than eGFRcr was associated with significantly higher rates of all-cause mortality, cardiovascular events, and kidney failure.

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Publication Details

Journal
JAMA
Published
2025-11-07
DOI
https://doi.org/10.1001/jama.2025.17578
Citations
3
Primary Topic
Chronic Kidney Disease and Diabetes
Type
article
Field-Weighted Citation Impact
4.29
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article

Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes

Ron T. Gansevoort, Lyanne M. Kieneker, Narayan Prasad, Dorothea Nitsch et al.
3 citations
JAMA
Chronic Kidney Disease and Diabetes
4.29
article

Discordance in Creatinine- and Cystatin C–Based eGFR and Clinical Outcomes

Ron T. Gansevoort, Lyanne M. Kieneker, Narayan Prasad, Dorothea Nitsch, Ben Schöttker, Chi‐yuan Hsu, Kevan R. Polkinghorne, Vivek Kumar, Markus P. Schneider, Anne‐Laure Faucon, Vilmantas Giedraitis, Ulla T. Schultheiß, Mary Cushman, Joachim H. Ix, Antoine Créon, Edouard L. Fu, Jonathan Emberson, Tsuneo Konta, Andrew S. Levey, Morgan E. Grams, Robin W.M. Vernooij, Aditya Surapaneni, Manisha Sahay, Katharine L. Cheung, John Townend, Stephan J. L. Bakker, Ron T. Gansevoort, Michelle M. Estrella, Orlando M. Gutiérrez, Patrick Barry Mark, Josef Coresh, Teresa K. Chen, Angela Yee‐Moon Wang, Debbie L. Cohen, Hannah Stocker, Juan Jesús Carrero, Lesley A. Inker, Satoru Nagase, Martin Larson, Johan Ärnlöv, Bénédicte Stengel, Junta Tanaka, Kai‐Uwe Eckardt, Jennifer Susan Lees, Keiko Kabasawa, Anna Köttgen, Michael G. Shlipak, Marco van Londen, Steven J. Chadban, Daniel A Levy, Yingying Sang, Mark J. Sarnak, Hermann Brenner, Titilayo O. Ilori, Ashok K. Yadav, Shoshana H. Ballew, Marie-Hélène Metzger, Peggy Sekula, Ichiei Narita, Dietrich Rothenbacher, Nisha Bansal, Carina Flaherty, Amanda Anderson, Aurora Caldinelli, Wei Peter Yang, Shih‐Jen Hwang, Yumi Ito, Masafumi Watanabe, Yingying Sang, David C. Wheeler, Martin Landray, Anders Larsson, Kevan Polkinghorne, Natalia Alencar de Pinho, Kunihiro Matsushita, Kazunobu Ichikawa
article en
3 citations

Abstract

In the CKD-PC, 11% of outpatient participants and 35% of hospitalized patients had an eGFRcys that was at least 30% lower than their eGFRcr. In the outpatient setting, presence of eGFRcys at least 30% lower than eGFRcr was associated with significantly higher rates of all-cause mortality, cardiovascular events, and kidney failure.

JAMAVol. 334(21)
University of Vermont (US), Yamagata University (JP), Dalarna University (SE), Tufts Medical Center (US), National Institutes of Health (US), University Medical Center Groningen (NL), Inserm (FR), University of Groningen (NL), German Cancer Research Center (DE), Friedrich-Alexander-Universität Erlangen-Nürnberg (DE), Utrecht University (NL), Heidelberg University (DE), Université Paris-Saclay (FR), UC San Diego Health System (US), Kidney Research UK (GB), Monash Medical Centre (AU), Karolinska Institutet (SE), University Medical Center Utrecht (NL), University of California San Diego (US), Universitätsklinikum Erlangen (DE), VA San Diego Healthcare System (US), Centre de recherche en Epidémiologie et Santé des Populations (FR), National Heart, Lung, and Blood Institute (US), Monash Health (AU), San Francisco VA Health Care System (US), Queen Elizabeth University Hospital (GB), University College London (GB), Post Graduate Institute of Medical Education and Research (IN), Monash University (AU), New York University (US), Niigata University (JP), Charité - Universitätsmedizin Berlin (DE), University of Glasgow (GB), University of Pennsylvania (US)
Openalex Percentile: Top 5%
Chronic Kidney Disease and Diabetes
4.29
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