A paradigm shift in DENV-4 clinical presentation: A viewpoint on pulmonary inflammatory symptoms from the 2023 Lincang outbreak
In this genotype I DENV-4 cohort, lower-respiratory manifestations were common, formed a coherent symptom network, and showed signals of association with severity. These findings support routine respiratory screening, pulse oximetry, and stepwise imaging in dengue care pathways, with validation needed in multicenter studies.
Authors
- Shuo Kou
- Bo Zhang (ORCID: https://orcid.org/0000-0003-2244-5388)
- Canrong Lu (ORCID: https://orcid.org/0000-0003-2292-9913)
- Xiangyu Yan (ORCID: https://orcid.org/0000-0002-1496-0358)
- Handong Xu (ORCID: https://orcid.org/0000-0001-7925-1985)
- Fuying Guo
- Tiejun Shui (ORCID: https://orcid.org/0000-0002-2224-0545)
- Wei Li (ORCID: https://orcid.org/0000-0003-2898-3988)
- Peng Wang (ORCID: https://orcid.org/0000-0002-3747-2867)
- Ling Zhang (ORCID: https://orcid.org/0009-0004-9173-1032)
Institutions
- Memorial Sloan Kettering Cancer Center (US)
- Tianjin University (CN)
- Hainan University (CN)
- Yunnan Provincial Hospital of Traditional Chinese Medicine (CN)
- Living Independently Now Center (US)
- Yunnan Center for Disease Control And Prevention (CN)
- Jingning County People's Hospital (CN)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1371/journal.pntd.0013679
- Primary Topic
- Mosquito-borne diseases and control
- Type
- article
- Field-Weighted Citation Impact
- 0.00