The role of hypothyroidism in cirrhosis pathogenesis: A retrospective cohort study and multi-omics integration analysis
This study is the first to reveal a causal relationship between hypothyroidism and cirrhosis, potentially driven by immune dysregulation mediated by HLA-DQA1 and CD27. These findings offer novel insights into disease progression and identify HLA-DQA1 and CD27 as potential therapeutic targets, with glycyrrhizic acid and levothyroxine sodium as promising candidate drugs.
Authors
- Tao Yang (ORCID: https://orcid.org/0000-0003-2002-7326)
- Weixuan Liang (ORCID: https://orcid.org/0000-0002-3841-5549)
- Yiwei Lin (ORCID: https://orcid.org/0000-0002-3572-6165)
- Chengxin Gu
- Zhixin Xie (ORCID: https://orcid.org/0000-0002-9660-7311)
- Hao Deng (ORCID: https://orcid.org/0000-0002-6417-6406)
- Jiyuan Zhou (ORCID: https://orcid.org/0000-0003-4244-7663)
- Jingyi Wu (ORCID: https://orcid.org/0000-0001-8064-097X)
- Jingwen Deng (ORCID: https://orcid.org/0000-0003-0668-0062)
- Qi Zhang (ORCID: https://orcid.org/0000-0002-7918-8952)
- Zhuofeng Wen
- Zhongxia Yang (ORCID: https://orcid.org/0000-0001-8156-442X)
- Xiuling Fu
- Can Weng
- Hui Yang (ORCID: https://orcid.org/0009-0001-6253-357X)
Institutions
- Shantou University (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Shantou University Medical College (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PLoS Genetics
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1371/journal.pgen.1011947
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00