Radiation-triggered psoriasiform rash with systemic dissemination after prolonged PD-1 inhibitor therapy: A case report
This case supports the "two-hit hypothesis": prolonged PD-1 inhibition establishes a subclinical autoimmune state (first hit), and radiotherapy acts as a second hit, ultimately culminating in systemic toxicity. These findings underscore the necessity for long-term cutaneous surveillance during immunotherapy and rigorous dermatological assessment when combined with radiotherapy.
Authors
- Yan Hou (ORCID: https://orcid.org/0000-0002-9834-1561)
- Yuankang Xie (ORCID: https://orcid.org/0000-0001-5374-4626)
- Mukun Wu (ORCID: https://orcid.org/0000-0001-5115-2280)
- Qingliang Xue (ORCID: https://orcid.org/0009-0000-6845-2570)
- Haizhen He (ORCID: https://orcid.org/0009-0009-0923-6267)
- Qian Yang (ORCID: https://orcid.org/0009-0007-5814-6466)
Institutions
- 117th Hospital of People's Liberation Army (CN)
- People's Liberation Army 401 Hospital (CN)
- CITIC Group (China) (CN)
- 181st Hospital of Chinese People's Liberation Army (CN)
Publication Details
- Journal
- Medicine
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1097/md.0000000000045550
- Citations
- 1
- Primary Topic
- Psoriasis: Treatment and Pathogenesis
- Type
- article
- Field-Weighted Citation Impact
- 0.80