Clinical Impact of Genetic Alterations in Pediatric Papillary Thyroid Carcinoma: A Next-Generation Sequencing Study from Argentina
Interestingly, in our PTC cohort, the NGS panel was highly specific to detect molecular alterations. Fusions were more frequent at a younger age and in the ATA-2015 high-recurrence-risk group; however, it was not a determining factor to predict PTC outcome. Finally, detection of pathological germline mutations in genes involved in HTPS was useful for genetic counseling.
Authors
- Noelia Dujovne (ORCID: https://orcid.org/0000-0001-8284-7894)
- Elisa Vaiani (ORCID: https://orcid.org/0000-0002-6787-8120)
- Marta Ciaccio (ORCID: https://orcid.org/0000-0002-8167-0713)
- Roxana Marino (ORCID: https://orcid.org/0000-0003-4737-3042)
- Víctor Ayarzabal
- Pablo Ramírez (ORCID: https://orcid.org/0000-0002-9193-7119)
- Natalia Pérez Garrido (ORCID: https://orcid.org/0000-0002-6020-2056)
- Alicia Belgorosky (ORCID: https://orcid.org/0000-0002-4234-400X)
- Natalia Gazek
- Jéssica López Marti
- Viviana Herzovich
Institutions
- National Technological University (AR)
- Garrahan Hospital (AR)
- Centro Científico Tecnológico - San Juan (AR)
Publication Details
- Journal
- Hormone Research in Paediatrics
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1159/000549332
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00