Establishment of a Novel Organoid Line from Esophageal Squamous Cell Carcinoma with Cytoplasmic Vacuoles: Association of Autolysosome Swelling with Vacuole Formation
We established a novel organoid line, ECO_Vac, as a useful model for investigating the molecular pathogenesis of ESCCV. By using ECO_Vac, we demonstrated that the cytoplasmic vacuoles in ESCCV were unphysiologically enlarged autolysosomes.
Authors
- Haruto Nishida (ORCID: https://orcid.org/0000-0003-2959-8002)
- Y Itai (ORCID: https://orcid.org/0000-0002-7108-1712)
- Shinji Yano
- Takafumi Fuchino
- Sohei Matsumoto (ORCID: https://orcid.org/0000-0003-4916-2177)
- Tomotaka Shibata (ORCID: https://orcid.org/0000-0001-8797-8877)
- Chisato Nakada (ORCID: https://orcid.org/0000-0002-4172-2814)
- Naoki Hijiya (ORCID: https://orcid.org/0000-0003-3775-8395)
- Kazuhiro Mizukami (ORCID: https://orcid.org/0000-0002-3148-8884)
- Tomonori Akagi (ORCID: https://orcid.org/0000-0002-0722-0343)
- Yuka Hirashita (ORCID: https://orcid.org/0000-0002-8111-8638)
- Tsutomu Daa (ORCID: https://orcid.org/0000-0001-5060-9883)
- Shoichi Fumoto
- Yoshiyuki Tsukamoto (ORCID: https://orcid.org/0000-0002-2827-8974)
- Shigeo Ninomiya (ORCID: https://orcid.org/0000-0002-3608-2146)
- Shusaku Kurogi
- Tsuyoshi Etoh
- Yuki Shitomi
- Masafumi Inomata (ORCID: https://orcid.org/0000-0002-8475-3688)
- Shunsuke Fujita
- Masatsugu Moriyama
Institutions
- Oita University (JP)
- Nakamura Memorial Hospital (JP)
Publication Details
- Journal
- Pathobiology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1159/000548788
- Citations
- 1
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.05