Aristolochic Acid and Alternative Lengthening of Telomeres Mechanisms Underlie Liver Angiosarcoma Pathogenesis
Our study provides compelling evidence that aristolochic acid exposure is associated with liver angiosarcoma, and elaboration of ALT activation in liver angiosarcomas offers new insights into their underlying biology and may guide the development of targeted therapeutic approaches.
Authors
- Hsueh‐Ping Chu (ORCID: https://orcid.org/0000-0002-0281-0942)
- Shih‐Chiang Huang (ORCID: https://orcid.org/0000-0002-5092-4434)
- Ann‐Lii Cheng (ORCID: https://orcid.org/0000-0002-9152-6512)
- Chia‐Lang Hsu (ORCID: https://orcid.org/0000-0002-7447-8045)
- Tom Wei‐Wu Chen (ORCID: https://orcid.org/0000-0003-4112-4029)
- Koping Chang (ORCID: https://orcid.org/0000-0001-7873-3640)
- Fu-Jen Hsueh (ORCID: https://orcid.org/0009-0000-6484-0090)
- Chiun Hsu (ORCID: https://orcid.org/0000-0002-1122-0055)
- Yu‐Chieh Tsai (ORCID: https://orcid.org/0000-0002-9285-7655)
- Chung‐Hsing Chen (ORCID: https://orcid.org/0000-0002-1205-7368)
- Chun-Hung Kuo (ORCID: https://orcid.org/0000-0003-0076-1929)
- Jen‐Chieh Lee (ORCID: https://orcid.org/0000-0003-3332-563X)
Institutions
- National Taiwan University (TW)
- Chang Gung University (TW)
- Linkou Chang Gung Memorial Hospital (TW)
- National Taiwan University Hospital (TW)
Publication Details
- Journal
- Liver Cancer
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1159/000549466
- Primary Topic
- Nephrotoxicity and Medicinal Plants
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chang Gung Medical Foundation
- National Taiwan University Hospital
- National Taiwan University
- National Science and Technology Council