Targeting FoxO1-STX17-mediated autophagic flux: Quercetin's therapeutic mechanism in diabetic nephropathy
Quercetin alleviates DN by targeting FoxO1 to restore STX17-dependent autophagosome-lysosome fusion, thereby resolving autophagic stress. These findings support quercetin as a promising therapeutic candidate for DN.
Authors
- Jingqian Xi (ORCID: https://orcid.org/0009-0004-4905-818X)
- Dongyi Wang (ORCID: https://orcid.org/0000-0002-1224-5529)
- Xiaoxue Cao (ORCID: https://orcid.org/0000-0002-5384-9265)
- Hongmei Lu (ORCID: https://orcid.org/0000-0002-9397-4757)
- Yuzi Cai
- Yachun Li
- Shujiao Zhang
- Jingyi Tang (ORCID: https://orcid.org/0000-0002-8754-5809)
- Baoluo Hou (ORCID: https://orcid.org/0009-0004-1772-2875)
- Jing Guo (ORCID: https://orcid.org/0009-0005-8497-9758)
Institutions
- Beijing University of Chinese Medicine (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Shanxi Province Hospital of Traditional Chinese Medicine (CN)
- Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine (CN)
- China Academy of Chinese Medical Sciences (CN)
- Shaanxi Provincial Hospital of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1016/j.ejphar.2025.178309
- Citations
- 1
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.35