MAX-FLASH: A compact multiangle x-ray system for clinical translation of FLASH radiotherapy
The emerging FLASH radiotherapy (FLASH-RT) technology, featuring ultrahigh dose rate (UHDR) instantaneous radiation to increase the response differences of normal tissues and tumors to ionizing radiation, is recognized as having significant clinical application value. A major challenge for its clinical translation, though, is achieving multiangle UHDR radiation at the millisecond time scale, in a compact system, to combine the FLASH effect with precise radiotherapy techniques. Building upon breakthroughs in several technologies, this study presents a compact multiangle x-ray FLASH-RT (MAX-FLASH) system that can be installed in most hospital radiotherapy treatment rooms.
Authors
- Chuanjing Wang
- Wenhui Huang (ORCID: https://orcid.org/0000-0001-7929-5267)
- Focheng Liu (ORCID: https://orcid.org/0000-0002-3847-6640)
- Chuanxiang Tang
- Rui Qiu (ORCID: https://orcid.org/0000-0002-3511-6164)
- Ankang Hu (ORCID: https://orcid.org/0000-0002-0348-7454)
- Jiaru Shi (ORCID: https://orcid.org/0000-0002-2189-685X)
- Yunsheng Han
- Hao Zha (ORCID: https://orcid.org/0000-0001-5416-6557)
- Qiang Gao (ORCID: https://orcid.org/0000-0001-7860-6692)
- Xiaowu Deng (ORCID: https://orcid.org/0000-0003-2923-1251)
- Xiaotong Zhang (ORCID: https://orcid.org/0009-0007-6723-1195)
- Jian Wang (ORCID: https://orcid.org/0000-0003-3989-9538)
- Liang Zhang (ORCID: https://orcid.org/0000-0002-4813-2251)
- Weiping Wang (ORCID: https://orcid.org/0000-0002-6619-1191)
- Junli Li (ORCID: https://orcid.org/0000-0002-3888-5735)
- Ke Hu (ORCID: https://orcid.org/0000-0002-1627-7659)
- Guoqing Liu (ORCID: https://orcid.org/0000-0001-8260-7495)
- He Yu (ORCID: https://orcid.org/0000-0002-4639-1321)
- Qiang Yan (ORCID: https://orcid.org/0000-0001-8855-9834)
- Fusheng Zhang (ORCID: https://orcid.org/0000-0001-8585-5478)
- Jinsheng Liu (ORCID: https://orcid.org/0000-0003-0759-2689)
- Hongyu Zhu (ORCID: https://orcid.org/0000-0003-4136-0910)
- Yaohong Liu (ORCID: https://orcid.org/0000-0002-0862-9378)
- Jiaqi Qiu (ORCID: https://orcid.org/0000-0002-9178-6998)
- Chenlei Guo (ORCID: https://orcid.org/0009-0006-8787-3489)
- Huaibi Chen
- Yinuo Zhu
- Kuo Men (ORCID: https://orcid.org/0000-0001-9754-2241)
Institutions
- Sun Yat-sen University (CN)
- Shenzhen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking Union Medical College Hospital (CN)
- China National Chemical Engineering (China) (CN)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Nuctech (China) (CN)
- Sun Yat-sen University Cancer Center (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Physical Review Applied
- Published
- 2025-09-30
- DOI
- https://doi.org/10.1103/mwx6-j35g
- Primary Topic
- Radiation Therapy and Dosimetry
- Type
- article
- Field-Weighted Citation Impact
- 0.00