The Role of Cytomegalovirus-specific Immunoglobulins as Modulators of Antigen-specific T-cell Expansion In Vitro
CMV-IVIg did not have any effect on immediate T-cell effector function. However, the marked effect of CMV-IVIg on increasing the proliferation of CMV-specific T cells while concomitantly reducing polyclonal T-cell function may have implications for the therapeutic use of immunoglobulins to restore CMV-specific T cells in patients with active CMV infection without increasing the alloreactive burden.
Authors
- Martina Sester (ORCID: https://orcid.org/0000-0001-5482-0002)
- Janine Mihm (ORCID: https://orcid.org/0000-0002-0357-6828)
- Tina Schmidt (ORCID: https://orcid.org/0000-0001-7929-5283)
- Amina Abu‐Omar (ORCID: https://orcid.org/0000-0003-2257-6046)
- Danilo Fliser
- David Schmit
- Saskia Bronder (ORCID: https://orcid.org/0000-0001-5863-1268)
- Urban Sester (ORCID: https://orcid.org/0000-0003-4007-5595)
Institutions
- Westpfalz Klinikum (DE)
- Saarland University (DE)
Publication Details
- Journal
- Transplantation Direct
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1097/txd.0000000000001877
- Primary Topic
- Cytomegalovirus and herpesvirus research
- Type
- article
- Field-Weighted Citation Impact
- 0.00