Mapping the developmental path for Parkinson’s disease therapeutics
The National Institute of Neurological Disorders and Stroke (NINDS) held an open workshop on April 23 and 24, 2024 to evaluate the gap between the current understanding of Parkinson’s disease (PD) and the development of therapeutics for treating PD. Representatives from key stakeholder groups discussed strategies for leveraging research to bridge this gap. Sessions focused on PD heterogeneity, target validation, development of tools and resources to facilitate therapeutics development, biomarker discovery and use, similarities and differences with PD-adjacent neurodegenerative diseases, and best practices for accelerating the therapeutics development process. Here are some of the main takeaways from the workshop.
Authors
- Hyun Joo Cho (ORCID: https://orcid.org/0000-0002-5926-7864)
- Beth-Anne Sieber (ORCID: https://orcid.org/0000-0002-5400-7254)
- Lauren A. Laboissonniere (ORCID: https://orcid.org/0000-0002-4260-5900)
- Amir P. Tamiz (ORCID: https://orcid.org/0000-0002-5345-970X)
- Rebecca B. Price (ORCID: https://orcid.org/0000-0002-7590-4325)
- Lyn B. Jakeman (ORCID: https://orcid.org/0000-0002-1760-8819)
- Shireen A. Sarraf (ORCID: https://orcid.org/0000-0001-8489-6198)
- William J. Martin (ORCID: https://orcid.org/0000-0002-2027-5859)
- Carl Wonders
- Alice Chen‐Plotkin (ORCID: https://orcid.org/0000-0002-3387-2038)
- Christine L. Torborg
- Christine Swanson‐Fischer
- Rebekah Corlew (ORCID: https://orcid.org/0000-0001-7000-8209)
- Neel T. Dhruv (ORCID: https://orcid.org/0000-0001-7112-8501)
- Sarah Robinson Schwartz
Institutions
- Johnson & Johnson (United States) (US)
- National Institute of Neurological Disorders and Stroke (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- npj Parkinson s Disease
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1038/s41531-025-01154-1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Australian Government
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke