Unraveling the Effects and Characteristics of Proliferating Tumor and Cytotoxic T Cells in Colorectal Cancer
Tumor cell proliferation is a marker for better prognosis in colorectal cancer. Although proliferating cytotoxic T cells demonstrate stronger prognostic value than nonproliferating cytotoxic T cells, spatial proximity to tumor cells diminishes this difference. These findings provide new insights into the interplay between tumor proliferation, immune response, and patient outcomes in colorectal cancer.
Authors
- Maarit Ahtiainen (ORCID: https://orcid.org/0000-0002-3263-2307)
- Hanna Elomaa (ORCID: https://orcid.org/0000-0002-5378-7703)
- Ville K. Äijälä (ORCID: https://orcid.org/0009-0005-7664-8027)
- Juha Saarnio (ORCID: https://orcid.org/0000-0002-8443-3625)
- Olli Helminen (ORCID: https://orcid.org/0000-0001-9544-6475)
- Tero Rautio (ORCID: https://orcid.org/0000-0003-4441-9412)
- Jan Böhm (ORCID: https://orcid.org/0000-0001-9664-588X)
- Erkki‐Ville Wirta (ORCID: https://orcid.org/0000-0002-2255-6136)
- Toni T. Seppälä (ORCID: https://orcid.org/0000-0002-4940-3498)
- Meeri Kastinen (ORCID: https://orcid.org/0009-0007-0954-5612)
- Markus J. Mäkinen (ORCID: https://orcid.org/0000-0002-9200-4118)
- Päivi Sirniö (ORCID: https://orcid.org/0000-0002-3988-3782)
- Vesa‐Matti Pohjanen (ORCID: https://orcid.org/0000-0002-4129-4346)
- Jukka‐Pekka Mecklin (ORCID: https://orcid.org/0000-0003-4895-2249)
- Jouni Härkönen (ORCID: https://orcid.org/0000-0002-1201-4288)
- Henna Karjalainen (ORCID: https://orcid.org/0009-0008-4694-6703)
- Jukka M. J. Rintala (ORCID: https://orcid.org/0000-0003-1865-8444)
- Juha P. Väyrynen (ORCID: https://orcid.org/0000-0002-8683-2996)
- Anne Tuomisto (ORCID: https://orcid.org/0000-0002-9949-1887)
- Vilja V. Tapiainen (ORCID: https://orcid.org/0009-0003-6306-6525)
- Sanna Meriläinen (ORCID: https://orcid.org/0000-0002-5418-4373)
- Onni Sirkiä (ORCID: https://orcid.org/0009-0003-8142-7144)
Institutions
- University of Helsinki (FI)
- Tampere University (FI)
- University of Eastern Finland (FI)
- Oulu University Hospital (FI)
- Helsinki University Hospital (FI)
- Tampere University Hospital (FI)
- Tampere University (FI)
- Central Finland Health Care District (FI)
- University of Jyväskylä (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2026
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Suomen Lääketieteen Säätiö
- Emil Aaltosen Säätiö
- Oulun Yliopisto
- Sigrid Juséliuksen Säätiö
- Syöpäsäätiö
- Biocenter Finland
- Biocenter, University of Oulu