Clostridioides difficile Infection Is Associated With Increased Colectomy Risk in Acute Severe Ulcerative Colitis Treated With Infliximab
C. difficile infection and a higher CRP/albumin ratio on admission are associated with decreased time to colectomy within 1 year of IFX among patients presenting with ASUC. These factors may aid in early risk stratification to minimize delays in JAK-inhibitor initiation or surgical referral.
Authors
- Aasma Shaukat (ORCID: https://orcid.org/0000-0003-2446-8858)
- Adam S. Faye (ORCID: https://orcid.org/0000-0002-1571-5856)
- David Hudesman (ORCID: https://orcid.org/0000-0001-8318-5271)
- Ariela Holmer (ORCID: https://orcid.org/0000-0003-0542-8439)
- Olivia Delau
- Simon Hong (ORCID: https://orcid.org/0000-0003-3802-1053)
- Tamara F. Kahan
- Jordan E. Axelrad (ORCID: https://orcid.org/0000-0003-1951-7790)
- Joshua Chodosh (ORCID: https://orcid.org/0000-0001-7784-4306)
- John Dodson (ORCID: https://orcid.org/0000-0002-0124-5910)
Institutions
- New York University (US)
Publication Details
- Journal
- Journal of Clinical Gastroenterology
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1097/mcg.0000000000002276
- Primary Topic
- Clostridium difficile and Clostridium perfringens research
- Type
- article
- Field-Weighted Citation Impact
- 0.00