Fatty acid-binding protein 4 drives microglia-mediated neuroinflammation through promoting S100A9 expression and lipid droplet accumulation after intracerebral hemorrhage
This study establishes that FABP4 acts as a novel orchestrator of post-ICH neuroinflammation through dual enzymatic and nonenzymatic pathways. We also demonstrate a targeted nanotherapeutic strategy to suppress FABP4 and improve neurological outcomes.
Authors
- Jiaqing He (ORCID: https://orcid.org/0000-0003-3954-6003)
- Zheng‐Hong Qin
- Xun Wu (ORCID: https://orcid.org/0000-0002-0620-8641)
- Yan Qu (ORCID: https://orcid.org/0000-0001-5434-7390)
- Tinghao Wang
- Haixiao Liu (ORCID: https://orcid.org/0000-0003-0994-2005)
- Hao Wu (ORCID: https://orcid.org/0000-0003-4694-7657)
- Wei Guo (ORCID: https://orcid.org/0000-0001-8888-3773)
- Yanni Xu (ORCID: https://orcid.org/0000-0003-1539-0606)
- Yaning Cai
- Pengjie Yang (ORCID: https://orcid.org/0000-0002-6089-2923)
Institutions
- Northwest University (CN)
- Xi'an Medical University (CN)
- First Affiliated Hospital of Gannan Medical University (CN)
- Tang Du Hospital (CN)
- Henan Medical University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s12974-025-03573-6
- Citations
- 3
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 4.17