Inhibition of Galectin-3 by ADSC-derived exosomes after cavernous nerve injury ameliorates erectile dysfunction by modulating oxidative stress and inflammatory profibrotic cascades
Collectively, this study demonstrates that upregulation of Gal-3 promotes the pathogenesis of CNI-ED by triggering oxidative stress and inflammatory profibrotic cascades and highlights the therapeutic potential of ADSC-Exo in restoring erectile function via Gal-3 inhibition.
Authors
- Tongxiang Diao (ORCID: https://orcid.org/0000-0001-9520-9971)
- Shuai Liu (ORCID: https://orcid.org/0000-0002-6259-2350)
- Feng Chen (ORCID: https://orcid.org/0000-0001-7169-9830)
- Guanbo Wang (ORCID: https://orcid.org/0000-0002-7500-3957)
- Ruiyu Li (ORCID: https://orcid.org/0000-0003-2074-4923)
- Qiang Fu (ORCID: https://orcid.org/0000-0002-1834-0041)
Institutions
- Shandong University (CN)
- Shandong Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-11-07
- DOI
- https://doi.org/10.1186/s13287-025-04749-w
- Citations
- 1
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province